Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TDP2 | O95551 | 2/20 | 0.31 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | SCNN1A | P37088 | 2/20 | 0.30 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL2021198 | 0.88 | MAPT (0.36) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Iodide SCHEMBL2017463 | 0.87 | KDM4E (0.33) | TDP1GABRA2LMNAMAPTSCNN1A | |
| SCHEMBL12635733 | 0.87 | MAPT (0.36) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Iodide SCHEMBL2016304 | 0.86 | GABRA2 (0.32) | GABRA2LMNASCNN1AELANE | |
| Iodide SCHEMBL2016658 | 0.85 | SCNN1A (0.38) | GABRA2LMNAMAPTSCNN1AKDM4E | |
| SCHEMBL12635720 | 0.85 | GABRA2 (0.32) | GABRA2LMNASCNN1AELANEKDM4E | |
| Iodide SCHEMBL2016509 | 0.83 | SCNN1A (0.39) | GABRA2LMNAMAPTSCNN1AKDM4E | |
| SCHEMBL12635715 | 0.83 | LMNA (0.44) | TDP1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL12635937 | 0.80 | DRD5 (0.38) | TDP1LMNAMAPTCXCR3SCNN1A | |
| Iodide SCHEMBL2021861 | 0.76 | KDM4E (0.35) | TDP1GABRA2LMNAMAPTSCNN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |