Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPY1R | P25929 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | NPY2R | P49146 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.32 |
| ▸ | CTSA | P10619 | 1/20 | 0.32 |
| ▸ | SCNN1A | P37088 | 5/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.30 |
| ▸ | TSHR | P16473 | 2/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL2021198 | 0.91 | MAPT (0.36) | ALDH1A1ADORA2AMAPTL3MBTL1LMNA | |
| SCHEMBL12635733 | 0.90 | MAPT (0.36) | ALDH1A1ADORA2AMAPTL3MBTL1LMNA | |
| Iodide SCHEMBL2016304 | 0.89 | GABRA2 (0.32) | RECQLLMNAGABRA2GABRB2SCNN1A | |
| Iodide SCHEMBL2021861 | 0.89 | KDM4E (0.35) | KDM4EALDH1A1ADORA2AMAPTNPY1R | |
| Iodide SCHEMBL2016658 | 0.89 | SCNN1A (0.38) | KDM4EALDH1A1ADORA2AMAPTMAOB | |
| SCHEMBL12635720 | 0.88 | GABRA2 (0.32) | KDM4EALDH1A1ADORA2ARECQLLMNA | |
| SCHEMBL12635727 | 0.87 | ALDH1A1 (0.36) | KDM4EALDH1A1ADORA2AMAPTNPY1R | |
| Iodide SCHEMBL2016067 | 0.87 | TDP1 (0.34) | KDM4EALDH1A1MAPTTDP1LMNA | |
| Iodide SCHEMBL2016509 | 0.86 | SCNN1A (0.39) | KDM4EALDH1A1ADORA2AMAPTMAOB | |
| SCHEMBL12635715 | 0.86 | LMNA (0.44) | KDM4EALDH1A1ADORA2AMAPTNPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |