Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA2 | P47869 | 2/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
| ▸ | SCNN1A | P37088 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12635720 | 0.99 | GABRA2 (0.32) | GABRA2GABRB2LMNAPDGFRACDK5 | |
| Iodide SCHEMBL2021198 | 0.90 | MAPT (0.36) | GABRA2GABRB2LMNA | |
| Iodide SCHEMBL2017463 | 0.89 | KDM4E (0.33) | GABRA2GABRB2LMNARECQLKMT2A | |
| SCHEMBL12635733 | 0.89 | MAPT (0.36) | GABRA2GABRB2LMNA | |
| Iodide SCHEMBL2014821 | 0.89 | KDM4E (0.33) | GABRA2GABRB2LMNAPDGFRACDK5 | |
| Iodide SCHEMBL2016658 | 0.88 | SCNN1A (0.38) | GABRA2GABRB2LMNAKMT2ASCNN1A | |
| SCHEMBL12636299 | 0.88 | ALDH1A1 (0.33) | GABRA2GABRB2LMNAPDGFRACDK5 | |
| Iodide SCHEMBL2016067 | 0.86 | TDP1 (0.34) | GABRA2LMNAELANESCNN1A | |
| Iodide SCHEMBL2016509 | 0.85 | SCNN1A (0.39) | GABRA2GABRB2LMNAKMT2ASCNN1A | |
| SCHEMBL12635715 | 0.85 | LMNA (0.44) | GABRA2GABRB2LMNARECQLKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | claimed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |