Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
| ▸ | LDHB | P07195 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28605586 | 0.75 | CYP2D6 (0.45) | CYP2D6KMT2AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL1045991 | 0.75 | SMN1; SMN2 (0.58) | CYP2D6KMT2AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL1045753 | 0.72 | ALDH1A1 (0.46) | CYP2D6KMT2AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL1045752 | 0.72 | ALDH1A1 (0.46) | CYP2D6KMT2AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL22383903 | 0.71 | LPO (0.41) | CYP2D6KMT2AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL2387567 | 0.70 | ESR1 (0.46) | ALDH1A1LMNAL3MBTL1TSHRHTT | |
| SCHEMBL2387569 | 0.70 | ESR1 (0.46) | ALDH1A1LMNAL3MBTL1TSHRHTT | |
| SCHEMBL7716484 | 0.70 | KMT2A (0.53) | CYP2D6KMT2AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL8492338 | 0.68 | — | — | |
| Biphenyl SCHEMBL27844503 | 0.66 | TSHR (0.46) | KMT2AKDM4ESMN1; SMN2NAMPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180133170-A1 | METHODS AND COMPOSITIONS FOR TREATING DISORDERS | ELI LILLY AND COMPANY | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180133170-A1 | METHODS AND COMPOSITIONS FOR TREATING DISORDERS | TRPA1, TRPV1, TRPV3 | CYP2D6 1573/4885KMT2A 4200/4885KDM4E 4704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.