SCHEMBL20162082

SCHEMBL20162082

Brc1ccc2c([c][c]c3cc(Br)ccc32)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 3/20 0.37
METAP2 P50579 1/20 0.37
JAK2 O60674 3/20 0.35
PDPK1 O15530 2/20 0.35
AHR P35869 3/20 0.35
ALOX15 P16050 1/20 0.35
ALDH1A1 P00352 2/20 0.33
ERN1 O75460 2/20 0.33
BCL2 P10415 1/20 0.33
HSP90AA1 P07900 1/20 0.33
TLR9 Q9NR96 1/20 0.33
S100A4 P26447 1/20 0.33
MAPK1 P28482 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
HTT P42858 1/20 0.32
CHEK1 O14757 1/20 0.32
AURKA O14965 1/20 0.32
DAPK3 O43293 1/20 0.32
PRKD3 O94806 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16158369 0.69 CYP2A6 (0.47) CYP2A6METAP2JAK2PDPK1AHR
SCHEMBL57643 0.67 ESR2 (0.46) CYP2A6METAP2JAK2PDPK1AHR
SCHEMBL14099591 0.67 ESR2 (0.42) CYP2A6METAP2JAK2PDPK1AHR
SCHEMBL31049230 0.65 BCL2 (0.50) CYP2A6METAP2JAK2PDPK1AHR
SCHEMBL56836 0.65 CYP2A6 (0.57) CYP2A6METAP2AHRALDH1A1ERN1
SCHEMBL30132916 0.65 GPR84 (0.41) CYP2A6METAP2JAK2PDPK1AHR
SCHEMBL13616030 0.65 BCL2 (0.45) CYP2A6METAP2JAK2PDPK1AHR
SCHEMBL1165315 0.65 GPR84 (0.41) CYP2A6METAP2JAK2PDPK1AHR
SCHEMBL6679360 0.65 GPR84 (0.41) CYP2A6METAP2JAK2PDPK1AHR
SCHEMBL2886196 0.63 CYP2A6 (0.33) CYP2A6AHRALOX15ALDH1A1HSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3323871-A2 ORGANIC HOLE TRANSPORTING COMPOUND USING P-DOPED CONJUGATED POLYMER ELECTROLYTE, ORGANIC ELECTRONIC DEVICE USING SAME, AND MANUFACTURING METHOD THEREFOR Konkuk University Industrial Cooperation Corp. (KR) 2018-05-23 EP disclosed