Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | PDE4A | P27815 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.62 |
| ▸ | MDH1 | P40925 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18256305 | 0.86 | MDH1 (0.57) | SMN1; SMN2KDM4EMDH1MEN1KMT2A | |
| SCHEMBL18256364 | 0.86 | HDAC10 (0.70) | SMN1; SMN2KDM4ECYP1A2CYP2D6PDE4A | |
| SCHEMBL12869137 | 0.84 | MDH1 (0.71) | SMN1; SMN2MDH1MEN1KMT2AHPGD | |
| SCHEMBL20163289 | 0.84 | HDAC3 (0.68) | SMN1; SMN2HDAC10HDAC6HPGDNPC1 | |
| SCHEMBL20179233 | 0.83 | MEN1 (0.68) | SMN1; SMN2KDM4ECYP1A2CYP2D6PDE4A | |
| SCHEMBL15581502 | 0.80 | HPGD (0.60) | SMN1; SMN2KDM4ECYP1A2CYP2D6PDE4A | |
| SCHEMBL12688128 | 0.80 | TDP1 (0.62) | SMN1; SMN2KDM4ECYP1A2CYP2D6PDE4A | |
| SCHEMBL18248630 | 0.79 | HDAC3 (0.68) | HDAC10HDAC6HPGD | |
| Bufexamac SCHEMBL25215 | 0.78 | KDM4E (1.00) | SMN1; SMN2KDM4ECYP1A2CYP2D6PDE4A | |
| Bufexamac SCHEMBL5076113 | 0.78 | KDM4E (1.00) | SMN1; SMN2KDM4ECYP1A2CYP2D6PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180141965-A1 | AUTOTAXIN INHIBITORS AND USES THEREOF | NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS (GR) | 2018-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180141965-A1 | AUTOTAXIN INHIBITORS AND USES THEREOF | ENPP2, SPINT2, SERPINB1 | SMN1; SMN2 4586/4885KDM4E 3185/4885CYP1A2 4651/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.