SCHEMBL20164217

SCHEMBL20164217

CCOC(=O)Nc1c(OC(=O)c2ccccc2)ccc2ccccc12

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.55
GLA P06280 1/20 0.55
POLB P06746 1/20 0.55
ALDH1A1 P00352 4/20 0.53
HPGD P15428 2/20 0.53
KMT2A Q03164 3/20 0.46
LMNA P02545 1/20 0.46
CDC25B P30305 2/20 0.43
CDC25A P30304 1/20 0.43
CDC25C P30307 1/20 0.43
SMN1; SMN2 Q16637 3/20 0.43
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
GAA P10253 1/20 0.43
MAPK1 P28482 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
CCR8 P51685 1/20 0.42
NCEH1 Q6PIU2 3/20 0.41
CRHBP P24387 1/20 0.41
CRHR2 Q13324 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28469300 0.82 KCNJ11 (0.54) KDM4EALDH1A1HPGDKMT2ALMNA
SCHEMBL20164271 0.81 ALDH1A1 (0.60) KDM4EGLAPOLBALDH1A1HPGD
SCHEMBL7187730 0.78 KDM4E (0.62) KDM4EGLAPOLBALDH1A1HPGD
SCHEMBL10447849 0.78 ALDH1A1 (0.71) KDM4EGLAPOLBALDH1A1HPGD
SCHEMBL20164221 0.78 HPGD (0.52) KDM4EGLAPOLBALDH1A1HPGD
SCHEMBL16236719 0.78 KMT2A (0.48) KDM4EALDH1A1KMT2ALMNACDC25B
SCHEMBL20164222 0.77 KMT2A (0.54) POLBALDH1A1HPGDKMT2ALMNA
SCHEMBL15535471 0.77 ALDH1A1 (0.56) KDM4EALDH1A1HPGDKMT2ALMNA
SCHEMBL25969910 0.76 NCEH1 (0.63) POLBALDH1A1KMT2ALMNASMN1; SMN2
SCHEMBL20164238 0.76 ALDH1A1 (0.56) KDM4EGLAPOLBALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3298048-B1 CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS BASELL POLIOLEFINE ITALIA SRL (IT) 2019-07-03 EP disclosed
US-10221256-B2 Catalyst components for the polymerization of olefins BASELL POLIOLEFINE ITALIA S.R.L. (IT) 2019-03-05 US disclosed
US-20180142044-A1 CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS BASELL POLIOLEFINE ITALIA S.R.L. (IT) 2018-05-24 US disclosed