SCHEMBL20164271

SCHEMBL20164271

CCOC(=O)Nc1ccc2ccccc2c1OC(=O)c1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.60
HPGD P15428 2/20 0.60
KMT2A Q03164 3/20 0.52
LMNA P02545 3/20 0.52
KDM4E B2RXH2 2/20 0.49
GLA P06280 1/20 0.49
POLB P06746 1/20 0.49
CDC25B P30305 2/20 0.46
CYP1A2 P05177 1/20 0.45
CYP2C9 P11712 1/20 0.45
CYP2C19 P33261 1/20 0.45
NOD2 Q9HC29 1/20 0.45
MAOB P27338 1/20 0.44
SMN1; SMN2 Q16637 4/20 0.44
CDC25A P30304 1/20 0.43
CDC25C P30307 1/20 0.43
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
GAA P10253 1/20 0.43
CRHBP P24387 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20164203 0.91 ALDH1A1 (0.55) ALDH1A1HPGDKMT2ALMNAKDM4E
SCHEMBL20164212 0.89 ALDH1A1 (0.53) ALDH1A1HPGDKMT2ALMNAKDM4E
SCHEMBL20164224 0.88 ALDH1A1 (0.55) ALDH1A1HPGDKMT2ALMNAKDM4E
SCHEMBL18249430 0.81 KMT2A (0.56) ALDH1A1HPGDKMT2ALMNAKDM4E
SCHEMBL20164217 0.81 KDM4E (0.55) ALDH1A1HPGDKMT2ALMNAKDM4E
SCHEMBL10447849 0.78 ALDH1A1 (0.71) ALDH1A1HPGDKMT2ALMNAKDM4E
SCHEMBL20164221 0.78 HPGD (0.52) ALDH1A1HPGDKMT2ALMNAKDM4E
SCHEMBL20164222 0.77 KMT2A (0.54) ALDH1A1HPGDKMT2ALMNAPOLB
SCHEMBL15534685 0.77 ALDH1A1 (0.53) ALDH1A1HPGDKMT2ALMNAKDM4E
SCHEMBL18249480 0.77 SMN1; SMN2 (0.55) ALDH1A1HPGDKMT2ALMNAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3298048-B1 CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS BASELL POLIOLEFINE ITALIA SRL (IT) 2019-07-03 EP disclosed
US-10221256-B2 Catalyst components for the polymerization of olefins BASELL POLIOLEFINE ITALIA S.R.L. (IT) 2019-03-05 US disclosed
US-20180142044-A1 CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS BASELL POLIOLEFINE ITALIA S.R.L. (IT) 2018-05-24 US disclosed