SCHEMBL20164267

SCHEMBL20164267

CCOC(=O)N(c1ccccc1)c1cc(C(C)(C)C)cc(C)c1OC(=O)c1ccc(Cl)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.38
SIRT3 Q9NTG7 1/20 0.37
L3MBTL1 Q9Y468 3/20 0.36
LMNA P02545 2/20 0.36
MAPT P10636 2/20 0.36
TDP1 Q9NUW8 1/20 0.36
ALDH1A1 P00352 6/20 0.35
KMT2A Q03164 5/20 0.35
MEN1 O00255 3/20 0.35
ELANE P08246 1/20 0.35
NPSR1 Q6W5P4 2/20 0.35
PTGER1 P34995 1/20 0.35
PTGER4 P35408 1/20 0.35
PTGER3 P43115 1/20 0.35
PTGER2 P43116 1/20 0.35
PTGIR P43119 1/20 0.35
PTGDR Q13258 1/20 0.35
RAB9A P51151 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2C9 P11712 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20164206 0.93 MAPT (0.42) L3MBTL1LMNAMAPTTDP1ALDH1A1
SCHEMBL20164245 0.90 LMNA (0.43) TP53L3MBTL1LMNAMAPTTDP1
SCHEMBL20164239 0.89 NPSR1 (0.38) L3MBTL1LMNAMAPTTDP1ALDH1A1
SCHEMBL20164286 0.85 GAA (0.38) TP53LMNAMAPTALDH1A1KMT2A
SCHEMBL20164246 0.85 TP53 (0.46) TP53SIRT3L3MBTL1LMNAMAPT
SCHEMBL18249379 0.84 KMT2A (0.39) TP53LMNAMAPTALDH1A1KMT2A
SCHEMBL20164290 0.80 RAB9A (0.35) TP53LMNAMAPTALDH1A1KMT2A
SCHEMBL20164281 0.80 TDP1 (0.44) L3MBTL1LMNAMAPTTDP1ALDH1A1
SCHEMBL20164273 0.79 MAPT (0.43) L3MBTL1LMNAMAPTTDP1ALDH1A1
SCHEMBL20164295 0.77 L3MBTL1 (0.41) TP53L3MBTL1LMNAMAPTTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3298048-B1 CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS BASELL POLIOLEFINE ITALIA SRL (IT) 2019-07-03 EP disclosed
US-10221256-B2 Catalyst components for the polymerization of olefins BASELL POLIOLEFINE ITALIA S.R.L. (IT) 2019-03-05 US disclosed
US-20180142044-A1 CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS BASELL POLIOLEFINE ITALIA S.R.L. (IT) 2018-05-24 US disclosed