Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.32 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.32 |
| ▸ | CTSC | P53634 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.31 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.31 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ULK1 | O75385 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 3/20 | 0.31 |
| ▸ | TDO2 | P48775 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20170132 | 0.79 | GABBR2 (0.36) | MAPTSOS1PIM1GABBR2GABBR1 | |
| SCHEMBL7181978 | 0.68 | MAPT (0.54) | KDM4EGAAMAPTPIM1GABBR2 | |
| SCHEMBL16904557 | 0.67 | CTSC (0.43) | KDM4EGAAMAPTSOS1CTSC | |
| SCHEMBL20356222 | 0.65 | ALDH1A1 (0.44) | KDM4EGAAMAPTULK1 | |
| SCHEMBL30657540 | 0.65 | ALDH1A1 (0.44) | KDM4EGAAMAPTULK1 | |
| SCHEMBL27723944 | 0.63 | CA1 (0.49) | KDM4EMAPTLMNA | |
| SCHEMBL355011 | 0.62 | ALDH1A1 (0.53) | KDM4EGAAMAPTLMNA | |
| SCHEMBL13280371 | 0.61 | YAP1 (0.49) | KDM4EMAPTGPR35 | |
| SCHEMBL496065 | 0.61 | ALDH1A1 (0.51) | KDM4EMAPTLMNA | |
| SCHEMBL16904560 | 0.61 | MALT1 (0.42) | SOS1GPR35CTSCLMNAULK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3323820-A1 | SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS | Epizyme, Inc. (US) | 2018-05-23 | — | — | EP | disclosed |