Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 3/20 | 0.36 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
| ▸ | IL1B | P01584 | 9/20 | 0.33 |
| ▸ | TNF | P01375 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20170334 | 0.79 | KDM4E (0.36) | GABBR2GABBR1LMNAMAPTIDO1 | |
| SCHEMBL19391537 | 0.71 | MEN1 (0.35) | LMNAMAPT | |
| SCHEMBL13280371 | 0.68 | YAP1 (0.49) | ALDH1A1MAPTHDAC8 | |
| SCHEMBL18830151 | 0.67 | YAP1 (0.51) | ALDH1A1LMNAMAPTHDAC8 | |
| SCHEMBL22877217 | 0.66 | GABBR2 (0.53) | GABBR2GABBR1ALDH1A1IL1B | |
| SCHEMBL7181978 | 0.63 | MAPT (0.54) | GABBR2GABBR1ALDH1A1LMNAMAPT | |
| SCHEMBL496065 | 0.62 | ALDH1A1 (0.51) | ALDH1A1LMNAMAPT | |
| SCHEMBL27362748 | 0.62 | HDAC8 (0.48) | ALDH1A1LMNAMAPTCRHBPCRHR2 | |
| SCHEMBL16904557 | 0.62 | CTSC (0.43) | LMNAMAPTSMN1; SMN2PIM1SOS1 | |
| SCHEMBL23936940 | 0.61 | CARM1 (0.41) | IDO1IL1BKCNH2NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3323820-A1 | SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS | Epizyme, Inc. (US) | 2018-05-23 | — | — | EP | disclosed |