Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 4/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20170680 | 0.91 | HCRTR1 (0.38) | HCRTR1HTR1AOPRM1OPRD1OPRK1 | |
| SCHEMBL20170745 | 0.82 | HCRTR1 (0.42) | HCRTR1HTR1AOPRM1OPRD1OPRK1 | |
| SCHEMBL20170667 | 0.77 | OPRM1 (0.32) | HCRTR1OPRM1OPRD1OPRK1 | |
| SCHEMBL18473622 | 0.77 | HCRTR1 (0.40) | HCRTR1OPRM1OPRD1OPRK1 | |
| SCHEMBL13847996 | 0.75 | OPRM1 (0.36) | HCRTR1OPRM1OPRD1OPRK1 | |
| SCHEMBL12826657 | 0.75 | HCRTR1 (0.41) | HCRTR1OPRM1OPRD1OPRK1 | |
| SCHEMBL14617397 | 0.74 | HTR1A (0.33) | HTR1AOPRM1OPRD1OPRK1 | |
| SCHEMBL19937935 | 0.73 | OPRM1 (0.38) | OPRM1OPRD1OPRK1 | |
| SCHEMBL12826656 | 0.69 | OPRM1 (0.32) | OPRM1 | |
| SCHEMBL14089364 | 0.68 | HCRTR1 (0.38) | HCRTR1OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |