Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 12/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 9/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20170829 | 0.79 | OPRD1 (0.46) | OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL14542485 | 0.72 | OPRM1 (0.43) | OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL22559865 | 0.72 | OPRM1 (0.43) | OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL20683158 | 0.65 | OPRM1 (0.67) | OPRM1OPRD1OPRK1 | |
| SCHEMBL20843777 | 0.65 | OPRM1 (0.67) | OPRM1OPRD1OPRK1 | |
| SCHEMBL20843778 | 0.65 | OPRM1 (0.67) | OPRM1OPRD1OPRK1 | |
| SCHEMBL20170726 | 0.65 | OPRM1 (0.43) | OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL17696682 | 0.65 | OPRD1 (0.42) | OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL21338056 | 0.64 | OPRD1 (0.40) | OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL14679543 | 0.63 | OPRM1 (0.50) | OPRM1OPRD1OPRK1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |