Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 10/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | MRGPRX2 | Q96LB1 | 2/20 | 0.36 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22559865 | 0.67 | OPRM1 (0.43) | OPRM1OPRD1SIGMAR1OPRK1MRGPRX2 | |
| SCHEMBL14542485 | 0.67 | OPRM1 (0.43) | OPRM1OPRD1SIGMAR1OPRK1MRGPRX2 | |
| SCHEMBL20170754 | 0.65 | OPRM1 (0.41) | OPRM1OPRD1SIGMAR1OPRK1 | |
| SCHEMBL20170829 | 0.64 | OPRD1 (0.46) | OPRM1OPRD1SIGMAR1OPRK1 | |
| Dihydromorphine SCHEMBL19615483 | 0.63 | OPRD1 (0.71) | OPRM1OPRD1OPRK1MRGPRX2SLC22A1 | |
| Dihydromorphine SCHEMBL13380388 | 0.63 | OPRD1 (0.71) | OPRM1OPRD1OPRK1MRGPRX2SLC22A1 | |
| Dihydromorphine SCHEMBL19645038 | 0.63 | OPRD1 (0.71) | OPRM1OPRD1OPRK1MRGPRX2SLC22A1 | |
| Dihydromorphine SCHEMBL26346 | 0.63 | OPRD1 (0.71) | OPRM1OPRD1OPRK1MRGPRX2SLC22A1 | |
| Dihydromorphine SCHEMBL17025853 | 0.63 | OPRD1 (0.71) | OPRM1OPRD1OPRK1MRGPRX2SLC22A1 | |
| Dihydromorphine SCHEMBL19107002 | 0.63 | OPRD1 (0.71) | OPRM1OPRD1OPRK1MRGPRX2SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |