Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12636672 | 0.99 | ELANE (0.33) | ELANEHPGDALDH1A1KDM4EGAA | |
| Iodide SCHEMBL2014821 | 0.93 | KDM4E (0.33) | ELANEHPGDALDH1A1KDM4EGAA | |
| SCHEMBL12636299 | 0.92 | ALDH1A1 (0.33) | ELANEHPGDALDH1A1KDM4EGAA | |
| Iodide SCHEMBL2016181 | 0.86 | SCNN1A (0.38) | ALDH1A1MEN1KMT2AGABRA2GABRB2 | |
| SCHEMBL12635737 | 0.85 | APAF1 (0.41) | HPGDALDH1A1KDM4EGAAALOX15 | |
| SCHEMBL12635760 | 0.85 | SCNN1A (0.38) | ALDH1A1MEN1KMT2AGABRA2GABRB2 | |
| Iodide SCHEMBL2053822 | 0.84 | SCNN1A (0.36) | ALOX15L3MBTL1POLBSMN1; SMN2 | |
| Iodide SCHEMBL2019947 | 0.84 | DRD5 (0.39) | ELANEHPGDALDH1A1KDM4EGAA | |
| Iodide SCHEMBL2021861 | 0.84 | KDM4E (0.35) | ELANEHPGDALDH1A1KDM4EGAA | |
| Iodide SCHEMBL2016304 | 0.83 | GABRA2 (0.32) | ELANELMNAKMT2AGABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |