Water

Water

SCHEMBL2017190

O.O=C=Nc1ccccc1.O=C=Nc1ccccc1

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR3E known ✓ A5X5Y0 1/20 0.35
HTR3B known ✓ O95264 1/20 0.35
HTR3A known ✓ P46098 1/20 0.35
HTR3D known ✓ Q70Z44 1/20 0.35
HTR3C known ✓ Q8WXA8 1/20 0.35
JAK2 known ✓ O60674 1/20 0.34
MEN1 known ✓ O00255 2/20 0.33
MIF P14174 1/20 0.52
CYP3A4 P08684 3/20 0.52
TSHR P16473 2/20 0.52
ALDH1A1 P00352 2/20 0.43
MAPK1 P28482 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
TRPA1 O75762 2/20 0.40
GABRA1 P14867 1/20 0.38
GABRB2 P47870 1/20 0.38
CYP1A2 P05177 1/20 0.37
SLC22A2 O15244 1/20 0.35
SLC22A1 O15245 1/20 0.35
SLC22A3 O75751 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL27798355 1.00 MIF (0.52) MIFCYP3A4TSHRALDH1A1MAPK1
Hydrochloric Acid SCHEMBL27783038 0.97 CYP3A4 (0.50) MIFCYP3A4TSHRALDH1A1MAPK1
SCHEMBL245090 0.97 MIF (0.55) MIFCYP3A4TSHRALDH1A1MAPK1
SCHEMBL19459346 0.97 MIF (0.55) MIFCYP3A4TSHRALDH1A1MAPK1
SCHEMBL5925 0.97
SCHEMBL1332539 0.97
Benzene SCHEMBL11510532 0.97 MIF (0.55) MIFCYP3A4TSHRALDH1A1MAPK1
Hydrogen Sulfide SCHEMBL2017797 0.94 MIF (0.52) MIFCYP3A4TSHRALDH1A1MAPK1
Methane SCHEMBL7027432 0.94 MIF (0.52) MIFCYP3A4TSHRALDH1A1MAPK1
Hydrochloric Acid SCHEMBL10809249 0.94 MIF (0.52) MIFCYP3A4TSHRALDH1A1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100240816-A1 EPOXY RESIN COMPOSITION CONTAINING ISOCYANURATES FOR USE IN ELECTRICAL LAMINATES DOW GLOBAL TECHNOLOGIES INC. (US) 2010-09-23 US claimed
EP-2207827-A1 EPOXY RESIN COMPOSITION CONTAINING ISOCYANURATES FOR USE IN ELECTRICAL LAMINATES Dow Global Technologies Inc. (US) 2010-07-21 EP claimed
WO-2009055666-A1 EPOXY RESIN COMPOSITION CONTAINING ISOCYANURATES FOR USE IN ELECTRICAL LAMINATES DOW GLOBAL TECHNOLOGIES INC. (US) 2009-04-30 WO claimed
EP-2909249-B1 CORE SHELL RUBBER MODIFIED SOLID EPOXY RESINS DOW GLOBAL TECHNOLOGIES LLC (US) 2019-07-31 EP disclosed
US-9701851-B2 Core shell rubber modified solid epoxy resins DOW GLOBAL TECHNOLOGIES LLC (US) 2017-07-11 US disclosed
EP-2909249-A2 CORE SHELL RUBBER MODIFIED SOLID EPOXY RESINS Dow Global Technologies LLC (US) 2015-08-26 EP disclosed
US-20150225576-A1 CORE SHELL RUBBER MODIFIED SOLID EPOXY RESINS DOW GLOBAL TECHNOLOGIES LLC 2015-08-13 US disclosed
WO-2014062531-A2 CORE SHELL RUBBER MODIFIED SOLID EPOXY RESINS DOW GLOBAL TECHNOLOGIES LLC (US) 2014-04-24 WO disclosed
US-20130251931-A1 NON-SINTERING ISOCYANATE MODIFIED EPOXY RESIN FOR FUSION BONDED EPOXY APPLICATIONS DOW GLOBAL TECHNOLOGIES LLC (US) 2013-09-26 US disclosed
EP-2205653-B1 NON-SINTERING ISOCYANATE MODIFIED EPOXY RESIN FOR FUSION BONDED EPOXY APPLICATIONS DOW GLOBAL TECHNOLOGIES LLC (US) 2013-04-24 EP disclosed
US-20110160327-A1 ISOCYANATE MODIFIED EPOXY RESIN FOR FUSION BONDED EPOXY FOAM APPLICATIONS DOW GLOBAL TECHNOLOGIES INC. (US) 2011-06-30 US disclosed
US-20100240816-A1 EPOXY RESIN COMPOSITION CONTAINING ISOCYANURATES FOR USE IN ELECTRICAL LAMINATES DOW GLOBAL TECHNOLOGIES INC. (US) 2010-09-23 US disclosed
US-20100227090-A1 NON-SINTERING ISOCYANATE MODIFIED EPOXY RESIN FOR FUSION BONDED EPOXY APPLICATIONS DOW GLOBAL TECHNOLOGIES LLC 2010-09-09 US disclosed
EP-2207827-A1 EPOXY RESIN COMPOSITION CONTAINING ISOCYANURATES FOR USE IN ELECTRICAL LAMINATES Dow Global Technologies Inc. (US) 2010-07-21 EP disclosed
EP-2205653-A2 NON-SINTERING ISOCYANATE MODIFIED EPOXY RESIN FOR FUSION BONDED EPOXY APPLICATIONS Dow Global Technologies Inc. (US) 2010-07-14 EP disclosed
EP-2193153-A1 ISOCYANATE MODIFIED EPOXY RESIN FOR FUSION BONDED EPOXY FOAM APPLICATIONS Dow Global Technologies Inc. (US) 2010-06-09 EP disclosed
WO-2009058715-A2 NON-SINTERING ISOCYANATE MODIFIED EPOXY RESIN FOR FUSION BONDED EPOXY APPLICATIONS DOW GLOBAL TECHNOLOGY INC. (US) 2009-05-07 WO disclosed
WO-2009055666-A1 EPOXY RESIN COMPOSITION CONTAINING ISOCYANURATES FOR USE IN ELECTRICAL LAMINATES DOW GLOBAL TECHNOLOGIES INC. (US) 2009-04-30 WO disclosed
WO-2009035860-A1 ISOCYANATE MODIFIED EPOXY RESIN FOR FUSION BONDED EPOXY FOAM APPLICATIONS DOW GLOBAL TECHNOLOGIES INC. (US) 2009-03-19 WO disclosed