Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.40 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.38 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 2/20 | 0.35 |
| ▸ | GABRD | O14764 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16291043 | 0.89 | MAPT (0.38) | MCHR1TLR8GABRPGABRDGABRA1 | |
| SCHEMBL720347 | 0.86 | SOAT1 (0.42) | TSHRTLR8SOAT1SMPD1GABRP | |
| SCHEMBL10188104 | 0.80 | ALDH1A1 (0.39) | TSHRTLR8GABRPGABRDGABRA1 | |
| SCHEMBL31548577 | 0.80 | GABRP (0.44) | TSHRTLR8SOAT1GABRPGABRD | |
| SCHEMBL11373823 | 0.79 | PIK3CD (0.37) | TSHR | |
| SCHEMBL15933181 | 0.77 | CA2 (0.39) | — | |
| SCHEMBL2237291 | 0.76 | HTR7 (0.46) | — | |
| SCHEMBL10187279 | 0.76 | MCHR1 (0.41) | MCHR1 | |
| SCHEMBL15114929 | 0.73 | LMNA (0.44) | TSHRSOAT1GABRPGABRDGABRA1 | |
| SCHEMBL18578440 | 0.73 | MCHR1 (0.56) | TSHRMCHR1TLR8SOAT1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3323414-A1 | INHIBITORS OF NEDD8-ACTIVATING ENZYME | Millennium Pharmaceuticals, Inc. (US) | 2018-05-23 | — | — | EP | disclosed |