Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.48 |
| ▸ | CLK2 | P49760 | 2/20 | 0.48 |
| ▸ | CLK3 | P49761 | 2/20 | 0.48 |
| ▸ | NAMPT | P43490 | 4/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | WNT1 | P04628 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20172442 | 0.86 | NAMPT (0.51) | MEN1KMT2ACYP11B2CYP11B1LMNA | |
| SCHEMBL20172513 | 0.77 | MEN1 (0.54) | MEN1KMT2ACYP11B2CYP11B1LMNA | |
| SCHEMBL20172431 | 0.74 | RAB9A (0.52) | MEN1KMT2ACYP11B2CYP11B1LMNA | |
| SCHEMBL17224950 | 0.71 | — | — | |
| SCHEMBL1003875 | 0.71 | ALDH1A1 (0.51) | MEN1KMT2ACYP11B2CYP11B1LMNA | |
| SCHEMBL30456292 | 0.68 | LMNA (0.62) | CYP11B2CYP11B1LMNANAMPTHIF1A | |
| SCHEMBL20172497 | 0.68 | TRPV1 (0.53) | CYP11B2CYP11B1LMNADYRK1ACLK2 | |
| SCHEMBL20172511 | 0.68 | TRPV1 (0.53) | CYP11B2CYP11B1LMNADYRK1ACLK2 | |
| SCHEMBL1003175 | 0.68 | SORT1 (0.50) | MEN1KMT2ACYP11B2CYP11B1LMNA | |
| SCHEMBL19064374 | 0.67 | HSD17B10 (0.64) | MEN1KMT2AHSD17B10POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3137459-B1 | MORPHOLIN-PYRIDINE DERIVATIVES HAVING AFFINITY TO THE TAAR1 RECEPTOR | HOFFMANN LA ROCHE (CH) | 2018-05-23 | — | — | EP | disclosed |