Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.62 |
| ▸ | CTSL | P07711 | 2/20 | 0.61 |
| ▸ | CAPN1 | P07384 | 3/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.53 |
| ▸ | CTSK | P43235 | 3/20 | 0.53 |
| ▸ | CAPN2 | P17655 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20653746 | 0.95 | CTSL (0.67) | RENCTSLSIRT2CTSK | |
| SCHEMBL21981425 | 0.93 | CAPN1 (0.58) | RENCTSLCAPN1CTSKCAPN2 | |
| SCHEMBL21981423 | 0.93 | CAPN1 (0.58) | RENCTSLCAPN1CTSKCAPN2 | |
| SCHEMBL21981346 | 0.92 | CAPN1 (0.59) | RENCTSLCAPN1SIRT2CTSK | |
| SCHEMBL20669092 | 0.92 | CAPN1 (0.59) | RENCTSLCAPN1SIRT2CTSK | |
| SCHEMBL18072615 | 0.91 | CTSL (0.61) | RENCTSLSIRT2 | |
| SCHEMBL17073778 | 0.91 | CTSL (0.64) | RENCTSLSIRT2CTSK | |
| SCHEMBL20173869 | 0.91 | REN (0.63) | RENPTPN1 | |
| SCHEMBL21219296 | 0.90 | REN (0.57) | RENCAPN1CAPN2 | |
| SCHEMBL21219294 | 0.90 | REN (0.57) | RENCAPN1CAPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10889543-B2 | Fine-tune modulators of neuronal excitability for neuropsychiatric disorders | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-01-12 | — | — | US | disclosed |
| US-20190270705-A1 | FINE-TUNE MODULATORS OF NEURONAL EXCITABILITY FOR NEUROPSYCHIATRIC DISORDERS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-09-05 | — | — | US | disclosed |
| WO-2018094335-A1 | FINE-TUNE MODULATORS OF NEURONAL EXCITABILITY FOR NEUROPSYCHIATRIC DISORDERS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2018-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10889543-B2 | Fine-tune modulators of neuronal excitability for neuropsychiatric disorders | CACNG6, KCNN3, SCN1B | REN 2892/4885CTSL 4409/4885CAPN1 2273/4885 |
| US-20190270705-A1 | FINE-TUNE MODULATORS OF NEURONAL EXCITABILITY FOR NEUROPSYCHIATRIC DISORDERS | CACNG6, KCNN3, SCN1B | REN 2892/4885CTSL 4409/4885CAPN1 2273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.