Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 4/20 | 0.63 |
| ▸ | KISS1R | Q969F8 | 3/20 | 0.59 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 3/20 | 0.51 |
| ▸ | CA2 | P00918 | 3/20 | 0.51 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.49 |
| ▸ | NPY4R | P50391 | 3/20 | 0.49 |
| ▸ | NPY1R | P25929 | 2/20 | 0.49 |
| ▸ | NPY2R | P49146 | 2/20 | 0.49 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.49 |
| ▸ | GNPAT | O15228 | 1/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20173872 | 0.92 | REN (0.59) | RENKISS1RNPY4RNPY1RNPY2R | |
| SCHEMBL20173867 | 0.91 | REN (0.62) | RENPTPN1 | |
| SCHEMBL23352495 | 0.88 | REN (0.56) | RENKISS1RPSEN1PSEN2APH1B | |
| SCHEMBL20516080 | 0.87 | REN (0.61) | RENPTPN1PSEN1PSEN2APH1B | |
| SCHEMBL20669327 | 0.87 | REN (0.61) | RENPTPN1PSEN1PSEN2APH1B | |
| SCHEMBL22962329 | 0.87 | REN (0.61) | RENPTPN1PSEN1PSEN2APH1B | |
| SCHEMBL28617005 | 0.87 | REN (0.61) | RENPTPN1PSEN1PSEN2APH1B | |
| SCHEMBL28617007 | 0.87 | REN (0.61) | RENPTPN1PSEN1PSEN2APH1B | |
| SCHEMBL30531002 | 0.87 | GNPAT (0.62) | PTPN2PTPN1CA1CA2GNPAT | |
| SCHEMBL22962260 | 0.86 | REN (0.61) | RENPTPN1PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10889543-B2 | Fine-tune modulators of neuronal excitability for neuropsychiatric disorders | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-01-12 | — | — | US | disclosed |
| US-20190270705-A1 | FINE-TUNE MODULATORS OF NEURONAL EXCITABILITY FOR NEUROPSYCHIATRIC DISORDERS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-09-05 | — | — | US | disclosed |
| WO-2018094335-A1 | FINE-TUNE MODULATORS OF NEURONAL EXCITABILITY FOR NEUROPSYCHIATRIC DISORDERS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2018-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10889543-B2 | Fine-tune modulators of neuronal excitability for neuropsychiatric disorders | CACNG6, KCNN3, SCN1B | REN 2892/4885KISS1R 2969/4885PTPN2 1660/4885 |
| US-20190270705-A1 | FINE-TUNE MODULATORS OF NEURONAL EXCITABILITY FOR NEUROPSYCHIATRIC DISORDERS | CACNG6, KCNN3, SCN1B | REN 2892/4885KISS1R 2969/4885PTPN2 1660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.