SCHEMBL20177518

SCHEMBL20177518

O=C(N[C@@H]1c2nccn2C[C@H]1c1c(F)cc(Cl)cc1F)OCc1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CCKBR P32239 1/20 0.41
BRD4 O60885 1/20 0.39
BRD2 P25440 1/20 0.39
BRD3 Q15059 1/20 0.39
CTSL P07711 1/20 0.38
CTSB P07858 1/20 0.38
CTSK P43235 1/20 0.38
ALDH1A1 P00352 1/20 0.38
GAA P10253 1/20 0.38
NAAA Q02083 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20177635 0.91 KDM1A (0.41) CCKBRCTSLCTSBCTSKALDH1A1
SCHEMBL18270477 0.89 FPR2 (0.45) CCKBRBRD4BRD2BRD3NAAA
SCHEMBL20177510 0.79 FPR2 (0.52) CTSLNAAA
SCHEMBL20177720 0.78 NAAA (0.41) CCKBRALDH1A1GAANAAA
SCHEMBL20177860 0.77 CCKBR (0.48) CCKBRCTSLCTSBCTSKALDH1A1
SCHEMBL20177491 0.75 CCKBR (0.47) CCKBRBRD4BRD2BRD3CTSL
SCHEMBL20177524 0.75 FPR2 (0.50)
SCHEMBL20177557 0.72 CA1 (0.42) BRD4BRD2BRD3
SCHEMBL18264306 0.72 FPR2 (0.48)
SCHEMBL18264305 0.72 FPR2 (0.48)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018092916-A1 NITROGEN-CONTAINING POLYCYCLIC HETEROCYCLIC DERIVATIVE 宇部興産株式会社 2018-05-24 WO disclosed