Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.40 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2014200 | 1.00 | ESR2 (0.42) | ESR2CRBNUSP30SMARCA2SMARCA4 | |
| SCHEMBL2018072 | 1.00 | ESR2 (0.42) | ESR2CRBNUSP30SMARCA2SMARCA4 | |
| SCHEMBL2015043 | 0.90 | CRBN (0.42) | CRBNUSP30SMARCA2SMARCA4PBRM1 | |
| SCHEMBL2015044 | 0.90 | CRBN (0.42) | CRBNUSP30SMARCA2SMARCA4PBRM1 | |
| SCHEMBL2018357 | 0.89 | CNR1 (0.42) | CRBNUSP30SMARCA2SMARCA4PBRM1 | |
| SCHEMBL2017220 | 0.89 | PAK1 (0.42) | CRBNUSP30SMARCA2SMARCA4PBRM1 | |
| SCHEMBL2018339 | 0.89 | FPR2 (0.43) | CRBNUSP30SMARCA2SMARCA4PBRM1 | |
| SCHEMBL2015350 | 0.87 | CRBN (0.40) | CRBNUSP30SMARCA2SMARCA4PBRM1 | |
| SCHEMBL2017289 | 0.86 | GPR119 (0.45) | CRBNUSP30SMARCA2SMARCA4PBRM1 | |
| SCHEMBL2013375 | 0.86 | SIGMAR1 (0.45) | CRBNUSP30SMARCA2SMARCA4PBRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110130382-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130382-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | HTR4, HTR1A, HTR1D | ESR2 566/4885CRBN 2432/4885USP30 4276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.