Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20179646 | 0.81 | GAA (0.43) | HPGDKMT2AMEN1CTSKGPR88 | |
| SCHEMBL6076593 | 0.78 | HPGD (1.00) | HPGDKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL20179645 | 0.76 | GPR88 (0.41) | HPGDKMT2AMEN1CTSKGPR88 | |
| SCHEMBL6075693 | 0.76 | KMT2A (1.00) | HPGDKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL20179556 | 0.75 | CTSK (0.48) | HPGDKMT2AMEN1CTSKGAA | |
| SCHEMBL20179460 | 0.75 | USP2 (0.43) | KMT2AMEN1GAANPSR1POLB | |
| SCHEMBL7355924 | 0.70 | METAP2 (0.60) | HPGDKMT2AMEN1CTSKPOLB | |
| SCHEMBL1107021 | 0.69 | GAA (0.62) | HPGDKMT2AMEN1GAANPSR1 | |
| Hydrochloric Acid SCHEMBL7355919 | 0.69 | METAP2 (0.59) | HPGDKMT2AMEN1CTSKPOLB | |
| SCHEMBL24799563 | 0.69 | HPGD (0.58) | HPGDKMT2AMEN1GAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018093695-A1 | FACTOR XIIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-05-24 | — | — | WO | disclosed |