Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 6/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SCNN1A | P37088 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2021620 | 0.93 | HTT (0.45) | ACSS2HTTKDM4EMEN1KMT2A | |
| SCHEMBL2018490 | 0.93 | KDM4E (0.53) | HTTSCNN1AKDM4ETSHRMEN1 | |
| SCHEMBL2017836 | 0.91 | HTT (0.46) | ACSS2HTTSCNN1AMEN1KMT2A | |
| SCHEMBL12635756 | 0.90 | HTT (0.49) | ACSS2HTTTSHRMEN1KMT2A | |
| SCHEMBL2019384 | 0.90 | HTT (0.41) | ACSS2HTTSCNN1AKDM4ETSHR | |
| SCHEMBL2015541 | 0.89 | HTT (0.46) | ACSS2HTTTSHR | |
| SCHEMBL2020396 | 0.88 | HTT (0.48) | ACSS2HTTMEN1KMT2AHDAC6 | |
| SCHEMBL2018438 | 0.88 | SCNN1A (0.44) | ACSS2HTTSCNN1A | |
| SCHEMBL2040435 | 0.88 | HTT (0.45) | ACSS2HTTTSHRMEN1KMT2A | |
| SCHEMBL2016331 | 0.87 | HTT (0.52) | ACSS2HTTSCNN1AKDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |