Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 9/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ESR1 | P03372 | 4/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20179806 | 0.89 | ELANE (0.38) | ELANEMAPTMEN1KMT2AESR1 | |
| SCHEMBL20165031 | 0.80 | ELANE (0.39) | ELANEMAPTMEN1KMT2AESR1 | |
| SCHEMBL29756860 | 0.80 | ELANE (0.39) | ELANEMAPTMEN1KMT2AESR1 | |
| SCHEMBL20179677 | 0.79 | ELANE (0.40) | ELANEMAPTMEN1KMT2ACA2 | |
| SCHEMBL24380625 | 0.77 | ELANE (0.38) | ELANEMAPTMEN1KMT2ACA2 | |
| SCHEMBL23336111 | 0.75 | ELANE (0.38) | ELANEMAPTMEN1KMT2ACA2 | |
| SCHEMBL20179807 | 0.72 | MAPT (0.38) | ELANEMAPTMEN1KMT2AESR1 | |
| SCHEMBL20179679 | 0.72 | LMNA (0.33) | ELANEMAPT | |
| SCHEMBL20179916 | 0.71 | — | — | |
| SCHEMBL20165456 | 0.70 | ELANE (0.38) | ELANEMAPTMEN1KMT2AESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018091153-A1 | NOVEL SUBSTITUTED N-(3-FLUOROPROPYL)-PYRROLIDINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC USES THEREOF | SANOFI (FR) | 2018-05-24 | — | — | WO | disclosed |