SCHEMBL20180138

SCHEMBL20180138

Brc1cccc(-n2ccc3cc(-c4ccccc4)ccc32)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 2/20 0.43
PLA2G4A P47712 1/20 0.41
HDAC3 O15379 1/20 0.40
HDAC4 P56524 1/20 0.40
HDAC1 Q13547 1/20 0.40
HDAC7 Q8WUI4 1/20 0.40
HDAC2 Q92769 1/20 0.40
HDAC10 Q969S8 1/20 0.40
HDAC11 Q96DB2 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
HDAC9 Q9UKV0 1/20 0.40
HDAC5 Q9UQL6 1/20 0.40
ROCK2 O75116 1/20 0.40
PIM1 P11309 1/20 0.40
PIM3 Q86V86 1/20 0.40
HSD11B1 P28845 1/20 0.40
DCTPP1 Q9H773 1/20 0.39
ABCG2 Q9UNQ0 1/20 0.37
BIRC5 O15392 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22515735 0.86 HTR6 (0.47) HTR6PLA2G4AHDAC3HDAC4HDAC1
SCHEMBL15138536 0.85 ALDH1A1 (0.47) HTR6PLA2G4AHDAC3HDAC4HDAC1
SCHEMBL6657897 0.84 CYP11B2 (0.55) NTSR1KMT2AMEN1
SCHEMBL22515750 0.83 HTR6 (0.49) HTR6PLA2G4AHDAC3HDAC4HDAC1
SCHEMBL17177970 0.82 PLA2G4A (0.46) HTR6PLA2G4AHDAC3HDAC4HDAC1
SCHEMBL6321218 0.81 BIRC5 (0.51) PLA2G4AHDAC3HDAC4HDAC1HDAC7
SCHEMBL20180240 0.80 HTR6 (0.42) HTR6PLA2G4AHDAC3HDAC4HDAC1
SCHEMBL3131128 0.79 PLA2G4A (0.51) PLA2G4AHDAC3HDAC4HDAC1HDAC7
SCHEMBL17026830 0.79 ROCK2 (0.55) PLA2G4AHDAC3HDAC4HDAC1HDAC7
SCHEMBL20180558 0.78 MEN1 (0.39) PLA2G4AHDAC3HDAC4HDAC1HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018093107-A1 ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT ELEMENT COMPRISING SAME 주식회사 두산 2018-05-24 WO disclosed