Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.61 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.61 |
| ▸ | HTR3B | O95264 | 3/20 | 0.61 |
| ▸ | HTR3A | P46098 | 3/20 | 0.61 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.61 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.61 |
| ▸ | DRD2 | P14416 | 2/20 | 0.61 |
| ▸ | DRD3 | P35462 | 2/20 | 0.61 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HTR7 | P34969 | 3/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.51 |
| ▸ | HTR1B | P28222 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24518342 | 0.82 | DRD2 (0.60) | HTR6DRD2DRD3MAPTHTR7 | |
| SCHEMBL233151 | 0.82 | HTR3A (0.71) | HTR6HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL6709128 | 0.82 | HTR3A (0.63) | HTR6HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL30747759 | 0.82 | HTR3A (0.71) | HTR6HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL30952473 | 0.81 | HTR3A (0.66) | HTR6HTR3EHTR3BHTR3AHTR3D | |
| Hydrochloric Acid SCHEMBL4905371 | 0.81 | HTR3A (0.69) | HTR6HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL4190135 | 0.81 | HTR6 (0.61) | HTR6HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL31651894 | 0.81 | HTR3E (0.77) | HTR6HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL8874392 | 0.81 | HTR3A (0.61) | HTR6HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL2875715 | 0.81 | HTR3A (0.66) | HTR6HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018090939-A1 | 8,9-DIHYDROIMIDAZOLE[1,2-A]PYRIMIDO[5,4-E]PYRIMIDINE-5(6H)-KETONE COMPOUND | 上海瑛派药业有限公司 | 2018-05-24 | — | — | WO | disclosed |