Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.46 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.44 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.44 |
| ▸ | CSF1R | P07333 | 2/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2018222 | 0.90 | MAPT (0.51) | TDP1MAPTNPC1RAB9ACYP1A2 | |
| SCHEMBL2020859 | 0.87 | TDP1 (0.53) | TDP1MAPTNPC1RAB9ACYP1A2 | |
| SCHEMBL16406373 | 0.81 | ACSS2 (0.53) | TDP1MAPTNPC1RAB9ACYP1A2 | |
| SCHEMBL21540396 | 0.77 | TDP1 (0.70) | TDP1MAPTNPC1RAB9ACYP1A2 | |
| SCHEMBL2043847 | 0.77 | PPARG (0.48) | TDP1MAPTNPC1RAB9ACYP1A2 | |
| SCHEMBL2015354 | 0.76 | PPARG (0.52) | TDP1MAPTNPC1RAB9ACYP1A2 | |
| SCHEMBL12636234 | 0.76 | MAPT (0.47) | TDP1MAPTNPC1RAB9ACYP1A2 | |
| SCHEMBL2016798 | 0.75 | KDM4E (0.44) | TDP1MAPTNPC1RAB9ACYP1A2 | |
| SCHEMBL2017353 | 0.74 | MAPT (0.52) | TDP1MAPTNPC1RAB9ACYP1A2 | |
| SCHEMBL9195588 | 0.73 | NLRP3 (0.55) | RAB9ANLRP3PPARGAAK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |