Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2020859 | 0.90 | TDP1 (0.53) | PPARGMAPTNPC1RAB9ACYP1A2 | |
| SCHEMBL2020612 | 0.89 | ACSS2 (0.56) | MAPTNPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL2018222 | 0.87 | MAPT (0.51) | PPARGMAPTNPC1RAB9ACYP1A2 | |
| SCHEMBL2015276 | 0.85 | PPARG (0.49) | PPARGMAPTACSS2KDM4EGAA | |
| SCHEMBL2020983 | 0.80 | LMNA (0.50) | PPARGMAPTNPC1RAB9ACYP1A2 | |
| SCHEMBL12635707 | 0.78 | PPARG (0.45) | PPARGMAPTNPC1RAB9ACYP1A2 | |
| SCHEMBL2019390 | 0.78 | BACE1 (0.41) | PPARGACSS2KDM4ETSHR | |
| SCHEMBL2018189 | 0.76 | TDP1 (0.53) | PPARGMAPTNPC1RAB9ACYP1A2 | |
| SCHEMBL2018088 | 0.76 | TNF (0.53) | MAPTNPC1RAB9AACSS2KDM4E | |
| SCHEMBL16406373 | 0.75 | ACSS2 (0.53) | MAPTNPC1RAB9ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |