Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | APEX1 | P27695 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27060029 | 1.00 | SMN1; SMN2 (0.34) | SMN1; SMN2TSHRTDP1APEX1CYP3A4 | |
| SCHEMBL14655259 | 0.88 | USP2 (0.35) | SMN1; SMN2TSHRTDP1APEX1CYP3A4 | |
| SCHEMBL4700582 | 0.88 | USP2 (0.35) | SMN1; SMN2TSHRTDP1APEX1CYP3A4 | |
| SCHEMBL4704755 | 0.86 | EPHX1 (0.34) | SMN1; SMN2ALDH1A1POLBL3MBTL1GAA | |
| SCHEMBL783029 | 0.81 | CDC42 (0.33) | TSHRTDP1APEX1CYP3A4MAPT | |
| SCHEMBL2411322 | 0.81 | BRD4 (0.31) | TSHRTDP1APEX1CYP3A4MAPT | |
| SCHEMBL14019942 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL28437820 | 0.79 | PTPN1 (0.33) | TDP1ALDH1A1MEN1KMT2A | |
| SCHEMBL11673561 | 0.78 | CYP1A2 (0.33) | MEN1KMT2A | |
| SCHEMBL22322452 | 0.78 | SMN1; SMN2 (0.33) | SMN1; SMN2ALDH1A1GAAUSP2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10093623-B2 | Cyclic amides as MetAP-2 inhibitors | MERCK PATENT GMBH (DE) | 2018-10-09 | — | — | US | claimed |
| US-12454523-B2 | Pyrazole derivatives | SYNGENTA CROP PROTECTION AG (CH) | 2025-10-28 | — | — | US | disclosed |
| US-20230286954-A1 | PYRAZOLE DERIVATIVES | SYNGENTA CROP PROTECTION AG (CH) | 2023-09-14 | — | — | US | disclosed |
| US-11680057-B2 | Pyrazole derivatives | SYNGENTA CROP PROTECTION AG (CH) | 2023-06-20 | — | — | US | disclosed |
| CN-115504920-A | Pyrrolidone and preparation method thereof | FMC公司 | 2022-12-23 | — | — | CN | disclosed |
| CN-110691516-B | Pyrrolidone and preparation method thereof | FMC公司 | 2022-10-28 | — | — | CN | disclosed |
| EP-3921306-A2 | PYRAZOLE DERIVATIVES | Syngenta Crop Protection AG (CH) | 2021-12-15 | — | — | EP | disclosed |
| WO-2020161148-A2 | PYRAZOLE DERIVATIVES | SYNGENTA CROP PROTECTION AG (CH) | 2020-08-13 | — | — | WO | disclosed |
| CN-110691516-A | Pyrrolidone and preparation method thereof | FMC公司 | 2020-01-14 | — | — | CN | disclosed |
| US-8871208-B2 | 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and uses thereof | ABBVIE INC. (US) | 2014-10-28 | — | — | US | disclosed |
| US-20110159005-A1 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11BETA-HSD1) INHIBITORS AND USES THEREOF | ABBOTT LABORATORIES (US) | 2011-06-30 | — | — | US | disclosed |
| WO-2011068927-A2 | 11-β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11B-HSD1) INHIBITORS AND USES THEREOF | ABBOTT LABORATORIES (US) | 2011-06-09 | — | — | WO | disclosed |
| CN-101437820-A | Heterobicyclic pyrazole compounds and methods of use | ARRAY BIOPHARMA INC (US) | 2009-05-20 | — | — | CN | disclosed |
| EP-0154490-A2 | Process for the preparation of pyrrolidone derivatives | I.S.F. Socièta per Azioni (IT) | 1985-09-11 | — | — | EP | disclosed |
| EP-0136658-A2 | -1-Benzyl-aminoalkyl-pyrrolidinones and their addition salts, process for their preparation and pharmaceutical compounds containing them | BOEHRINGER INGELHEIM KG (DE) | 1985-04-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230286954-A1 | PYRAZOLE DERIVATIVES | RB1, NQO2, RBX1 | SMN1; SMN2 4149/4885TSHR 2058/4885TDP1 1887/4885 |
| US-11680057-B2 | Pyrazole derivatives | RB1, NQO2, RBX1 | SMN1; SMN2 4149/4885TSHR 2058/4885TDP1 1887/4885 |
| US-12454523-B2 | Pyrazole derivatives | RB1, NQO2, RBX1 | SMN1; SMN2 4149/4885TSHR 2058/4885TDP1 1887/4885 |
| US-10093623-B2 | Cyclic amides as MetAP-2 inhibitors | METAP2, METAP1, LNPEP | SMN1; SMN2 4229/4885TSHR 718/4885TDP1 2635/4885 |
| US-20110159005-A1 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11BETA-HSD1) INHIBITORS AND USES THEREOF | HSD11B1, HSD17B1, HSD11B2 | SMN1; SMN2 3348/4885TSHR 3534/4885TDP1 1002/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.