Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4742742 | 1.00 | OPRM1 (0.44) | OPRM1OPRK1KDM4EALDH1A1LMNA | |
| SCHEMBL2488429 | 1.00 | OPRM1 (0.44) | OPRM1OPRK1KDM4EALDH1A1LMNA | |
| SCHEMBL6674978 | 0.85 | KDM4E (0.49) | OPRM1OPRK1KDM4EALDH1A1LMNA | |
| SCHEMBL9799315 | 0.84 | OPRM1 (0.42) | OPRM1OPRK1KDM4EALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL27535166 | 0.84 | KDM4E (0.48) | OPRM1OPRK1KDM4EALDH1A1LMNA | |
| SCHEMBL4435156 | 0.82 | LMNA (0.40) | OPRM1OPRK1KDM4EALDH1A1LMNA | |
| SCHEMBL28679829 | 0.81 | OPRM1 (0.40) | OPRM1OPRK1KDM4EALDH1A1LMNA | |
| SCHEMBL4440878 | 0.80 | LMNA (0.41) | OPRM1OPRK1ALDH1A1LMNAKMT2A | |
| SCHEMBL4448653 | 0.80 | LMNA (0.41) | OPRM1OPRK1ALDH1A1LMNAKMT2A | |
| SCHEMBL4438409 | 0.80 | LMNA (0.41) | OPRM1OPRK1ALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011077443-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF DULOXETINE HYDROCHLORIDE | BIOCON LIMITED (IN) | 2011-06-30 | — | — | WO | claimed |
| EP-1976844-A2 | IMPROVED PROCESS FOR PURE DULOXETINE HYDROCHLORIDE | MSN Laboratories Limited (IN) | 2008-10-08 | — | — | EP | claimed |
| EP-1971591-A2 | IMPROVED SYNTHESIS AND PREPARATIONS OF DULOXETINE SALTS | Medichem, S.A. (ES) | 2008-09-24 | — | — | EP | claimed |
| WO-2007096707-A2 | IMPROVED SYNTHESIS AND PREPARATIONS OF DULOXETINE SALTS | MEDICHEM S.A. (US) | 2007-08-30 | — | — | WO | claimed |
| WO-2007077580-A2 | IMPROVED PROCESS FOR PURE DULOXETINE HYDROCHLORIDE | MSN LABORATORIES LIMITED (IN) | 2007-07-12 | — | — | WO | claimed |
| CN-113429380-B | Preparation method of duloxetine | 新发药业有限公司 | 2022-07-01 | — | — | CN | disclosed |
| CN-113429380-A | Preparation method of duloxetine | 新发药业有限公司 | 2021-09-24 | — | — | CN | disclosed |
| WO-2011077443-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF DULOXETINE HYDROCHLORIDE | BIOCON LIMITED (IN) | 2011-06-30 | — | — | WO | disclosed |
| WO-2009087463-A2 | A METHOD FOR THE PREPARATION OF DULOXETINE HYDROCHLORIDE | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2009-07-16 | — | — | WO | disclosed |
| US-20090093645-A1 | SYNTHESIS AND PREPARATIONS OF DULOXETINE SALTS | MEDICHEM S.A. (ES) | 2009-04-09 | — | — | US | disclosed |
| EP-1976844-A2 | IMPROVED PROCESS FOR PURE DULOXETINE HYDROCHLORIDE | MSN Laboratories Limited (IN) | 2008-10-08 | — | — | EP | disclosed |
| EP-1971592-A2 | IMPROVED SYNTHESIS AND PREPARATIONS OF DULOXETINE SALTS | Medichem, S.A. (ES) | 2008-09-24 | — | — | EP | disclosed |
| EP-1971591-A2 | IMPROVED SYNTHESIS AND PREPARATIONS OF DULOXETINE SALTS | Medichem, S.A. (ES) | 2008-09-24 | — | — | EP | disclosed |
| WO-2008093360-A2 | A PROCESS FOR PREPARATION OF (S)-(+)-N-METHYL-3(1-NAPHTHYLOXY)-3(2-THIENYL)PROPYLAMINE HYDROCHLORIDE | USV LIMITED (IN) | 2008-08-07 | — | — | WO | disclosed |
| WO-2007119114-A2 | IMPROVED SYNTHESIS AND PREPARATIONS OF DULOXETINE SALTS | MEDICHEM, S.A. (US) | 2007-10-25 | — | — | WO | disclosed |
| WO-2007096707-A2 | IMPROVED SYNTHESIS AND PREPARATIONS OF DULOXETINE SALTS | MEDICHEM S.A. (US) | 2007-08-30 | — | — | WO | disclosed |
| WO-2007077580-A2 | IMPROVED PROCESS FOR PURE DULOXETINE HYDROCHLORIDE | MSN LABORATORIES LIMITED (IN) | 2007-07-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093645-A1 | SYNTHESIS AND PREPARATIONS OF DULOXETINE SALTS | SLC6A2, SLC6A4, CYP2D6 | OPRM1 138/4885OPRK1 53/4885KDM4E 603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.