Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27535166 | 0.98 | KDM4E (0.48) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL2018408 | 0.85 | OPRM1 (0.44) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL4742742 | 0.85 | OPRM1 (0.44) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL2488429 | 0.85 | OPRM1 (0.44) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL2376360 | 0.82 | OPRM1 (0.44) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL11201016 | 0.81 | ALOX5 (0.39) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL30082837 | 0.81 | OPRM1 (0.43) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL3243862 | 0.80 | OPRM1 (0.49) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL9799315 | 0.79 | OPRM1 (0.42) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL3742352 | 0.79 | OPRM1 (0.48) | KDM4EALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478645-A2 | QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS | Amgen Inc. (US) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003066630-A2 | QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS | AMGEN INC. (US) | 2003-08-14 | — | — | WO | disclosed |