Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2488429 | 0.82 | OPRM1 (0.44) | LMNATP53POLBTHRBNPSR1 | |
| SCHEMBL2018408 | 0.82 | OPRM1 (0.44) | LMNATP53POLBTHRBNPSR1 | |
| SCHEMBL4742742 | 0.82 | OPRM1 (0.44) | LMNATP53POLBTHRBNPSR1 | |
| SCHEMBL4448653 | 0.79 | LMNA (0.41) | LMNATP53POLBTHRBNPSR1 | |
| SCHEMBL4440878 | 0.79 | LMNA (0.41) | LMNATP53POLBTHRBNPSR1 | |
| SCHEMBL4438409 | 0.79 | LMNA (0.41) | LMNATP53POLBTHRBNPSR1 | |
| SCHEMBL6674978 | 0.72 | KDM4E (0.49) | LMNATP53POLBTHRBNPSR1 | |
| Hydrochloric Acid SCHEMBL27535166 | 0.70 | KDM4E (0.48) | LMNATP53POLBTHRBNPSR1 | |
| SCHEMBL4435152 | 0.70 | NPC1 (0.43) | LMNATP53POLBTHRBNPSR1 | |
| SCHEMBL11202255 | 0.70 | LMNA (0.43) | LMNATP53POLBTHRBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125772-A1 | A PROCESS FOR THE PREPARATION OF DULOXETIN AND NEW KEY INTERMEDIATES FOR USE THEREIN | Richter Gedeon NYRT (HU) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008078124-A1 | A PROCESS FOR THE PREPARATION OF DULOXETIN AND NEW KEY INTERMEDIATES FOR USE THEREIN | RICHTER GEDEON NYRT. (HU) | 2008-07-03 | — | — | WO | disclosed |