Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 3/20 | 0.32 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.32 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184306 | 0.84 | P2RX7 (0.38) | P2RX7PIM1 | |
| SCHEMBL15019739 | 0.69 | TRPM8 (0.35) | PPARG | |
| SCHEMBL16291350 | 0.65 | TACR3 (0.57) | P2RX7NPC1SMN1; SMN2 | |
| SCHEMBL15020409 | 0.64 | PPARG (0.39) | PPARG | |
| SCHEMBL13240633 | 0.63 | KDM4E (0.41) | NPC1RAB9ASMN1; SMN2TDP1ALPL | |
| SCHEMBL6968969 | 0.59 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2TDP1ALPL | |
| Dipyridyl SCHEMBL28150180 | 0.57 | KDM4E (0.61) | NPC1RAB9ASMN1; SMN2TDP1ALPL | |
| SCHEMBL16200073 | 0.57 | METAP1 (0.44) | NPC1RAB9ASMN1; SMN2TDP1ALPL | |
| SCHEMBL21239649 | 0.56 | PARP1 (0.45) | P2RX7NPC1SMN1; SMN2 | |
| SCHEMBL23199896 | 0.55 | LRRK2 (0.53) | NPC1RAB9ASMN1; SMN2TDP1ALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970267-B3 | P2X7 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-30 | — | — | EP | claimed |