Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 10/20 | 0.42 |
| ▸ | JAK2 | O60674 | 9/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184593 | 0.88 | GPR84 (0.48) | JAK3JAK2AXLCDK8 | |
| SCHEMBL20184581 | 0.88 | JAK3 (0.43) | JAK3JAK2 | |
| SCHEMBL20184357 | 0.88 | CHUK (0.47) | JAK3JAK2MAPK8CDC7PLK4 | |
| SCHEMBL20184548 | 0.87 | JAK3 (0.53) | JAK3JAK2DHODHCHEK1 | |
| SCHEMBL20184551 | 0.87 | JAK3 (0.53) | JAK3JAK2DHODH | |
| SCHEMBL20184525 | 0.86 | JAK2 (0.49) | JAK3JAK2AXLPRKAA1 | |
| SCHEMBL20184478 | 0.86 | JAK2 (0.53) | JAK3JAK2DHODHPDE4B | |
| SCHEMBL20184599 | 0.86 | JAK3 (0.53) | JAK3JAK2DHODH | |
| SCHEMBL20184489 | 0.84 | JAK2 (0.51) | JAK3JAK2DHODHAXLPRKAA1 | |
| SCHEMBL20184518 | 0.84 | PRKAB2 (0.48) | JAK3JAK2DHODHPRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |