Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 4/20 | 0.40 |
| ▸ | CTSL | P07711 | 5/20 | 0.39 |
| ▸ | CTSB | P07858 | 3/20 | 0.39 |
| ▸ | CTSS | P25774 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 5/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.37 |
| ▸ | CTSV | O60911 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 5/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184323 | 0.86 | JAK3 (0.41) | JAK2CDK8JAK3 | |
| SCHEMBL20184677 | 0.84 | F11 (0.43) | JAK2JAK3HSP90AB1 | |
| SCHEMBL20184417 | 0.84 | DYRK1A (0.45) | JAK2CDK8JAK3 | |
| SCHEMBL20184533 | 0.83 | JAK3 (0.52) | JAK2JAK3 | |
| SCHEMBL20184593 | 0.83 | GPR84 (0.48) | JAK2GPR84CDK8JAK3 | |
| SCHEMBL20184548 | 0.81 | JAK3 (0.53) | JAK2JAK3 | |
| SCHEMBL20184551 | 0.81 | JAK3 (0.53) | JAK2JAK3 | |
| SCHEMBL20184694 | 0.81 | JAK3 (0.47) | JAK2JAK3 | |
| SCHEMBL20184525 | 0.81 | JAK2 (0.49) | JAK2GPR84JAK3 | |
| SCHEMBL20184581 | 0.81 | JAK3 (0.43) | JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |