Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 4/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | ELANE | P08246 | 7/20 | 0.48 |
| ▸ | CTSG | P08311 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20187669 | 0.84 | STAT3 (0.57) | STAT3ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL20851855 | 0.83 | STAT3 (0.62) | STAT3ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL20187568 | 0.82 | STAT3 (0.92) | STAT3ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL20187646 | 0.82 | STAT3 (0.64) | STAT3ALDH1A1LMNARECQLMAPT | |
| SCHEMBL20187658 | 0.80 | STAT3 (0.58) | STAT3ALDH1A1MEN1KMT2ALMNA | |
| Napabucasin SCHEMBL29349770 | 0.80 | STAT3 (1.00) | STAT3ALDH1A1MEN1KMT2ALMNA | |
| Napabucasin SCHEMBL1883845 | 0.80 | STAT3 (1.00) | STAT3ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL1450113 | 0.78 | STAT3 (1.00) | STAT3ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL140417 | 0.75 | EGFR (0.60) | ALDH1A1MEN1KMT2ALMNAEGFR | |
| SCHEMBL8947495 | 0.74 | EGFR (0.73) | ALDH1A1MEN1KMT2ALMNAEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018096401-A1 | NEW NAPHTHO[2,3-B]FURAN DERIVATIVES | BAN HITOSHI (JP) | 2018-05-31 | — | — | WO | claimed |
| WO-2018096401-A1 | NEW NAPHTHO[2,3-B]FURAN DERIVATIVES | BAN HITOSHI (JP) | 2018-05-31 | — | — | WO | disclosed |