Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20194134 | 0.85 | ALDH1A1 (0.45) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL20194143 | 0.85 | ALDH1A1 (0.42) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL8302175 | 0.80 | F2 (0.56) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL20194121 | 0.78 | F2 (0.46) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL10401280 | 0.78 | F2 (0.46) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL3185582 | 0.74 | PBRM1 (0.55) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL20194129 | 0.74 | F2 (0.45) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL2481253 | 0.72 | F2 (0.59) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL20194123 | 0.71 | ALDH1A1 (0.47) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL7992447 | 0.70 | L3MBTL1 (0.38) | NPC1POLBNPSR1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054955-B1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-30 | — | — | EP | disclosed |