Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | PLG | P00747 | 1/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.45 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | DDX3X | O00571 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20194123 | 0.93 | ALDH1A1 (0.47) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL8302175 | 0.79 | F2 (0.56) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL6173497 | 0.75 | MGLL (0.57) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL20194121 | 0.74 | F2 (0.46) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL20194124 | 0.74 | F2 (0.46) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL10401280 | 0.74 | F2 (0.46) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL20119475 | 0.72 | P4HB (0.37) | GAASMN1; SMN2HPGDLMNAPOLB | |
| Bicarbonate SCHEMBL11473808 | 0.72 | MGLL (0.55) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL4230443 | 0.72 | DDX3X (0.65) | GAADDX3XSMN1; SMN2NPSR1HPGD | |
| SCHEMBL2481253 | 0.71 | F2 (0.59) | F2PLGPRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054955-B1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-30 | — | — | EP | disclosed |