Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.58 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.54 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.49 |
| ▸ | PELP1 | Q8IZL8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2248076 | 0.89 | HCAR3 (0.74) | HCAR3VCAM1KMT2AMAPTALDH1A1 | |
| SCHEMBL763439 | 0.87 | HCAR3 (0.62) | HCAR3VCAM1KMT2AMAPTALDH1A1 | |
| SCHEMBL5007870 | 0.86 | LMNA (0.57) | VCAM1KMT2AMAPTALDH1A1PKM | |
| SCHEMBL17263068 | 0.86 | ALDH1A1 (0.52) | HCAR3VCAM1KMT2AMAPTALDH1A1 | |
| SCHEMBL9195511 | 0.85 | HCAR3 (0.62) | HCAR3VCAM1KMT2AMAPTALDH1A1 | |
| SCHEMBL3060501 | 0.85 | HCAR3 (0.61) | HCAR3DCTPP1KMT2AMAPTALDH1A1 | |
| SCHEMBL20266487 | 0.85 | ALDH1A1 (0.67) | HCAR3VCAM1KMT2AMAPTALDH1A1 | |
| SCHEMBL1528372 | 0.85 | AR (0.55) | VCAM1KMT2AMAPTALDH1A1PKM | |
| SCHEMBL29560026 | 0.85 | ALDH1A1 (0.67) | HCAR3VCAM1KMT2AMAPTALDH1A1 | |
| SCHEMBL17184395 | 0.84 | LMNA (0.72) | VCAM1KMT2AMAPTALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10040767-B2 | Benzimidazole derivatives and uses thereof | PELOTON THERAPEUTICS, INC. (US) | 2018-08-07 | — | — | US | disclosed |
| US-20170088523-A1 | BENZIMIDAZOLE DERIVATIVES AND USES THEREOF | PELOTON THERAPEUTICS, INC. | 2017-03-30 | — | — | US | disclosed |
| WO-2015175845-A1 | BENZIMIDAZOLE DERIVATIVES AND USES THEREOF | PELOTON THERAPEUTICS, INC. (US) | 2015-11-19 | — | — | WO | disclosed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170088523-A1 | BENZIMIDAZOLE DERIVATIVES AND USES THEREOF | ACSS2, GLS2, ACSL3 | HCAR3 2019/4885DCTPP1 1695/4885VCAM1 3948/4885 |
| US-10040767-B2 | Benzimidazole derivatives and uses thereof | ACSS2, GLS2, ACSL3 | HCAR3 2019/4885DCTPP1 1695/4885VCAM1 3948/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.