SCHEMBL2019475

SCHEMBL2019475

C=C(c1ccc(Cl)c(Cl)c1)C(C)C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.47
HPGD P15428 1/20 0.46
NPFFR2 Q9Y5X5 1/20 0.46
SRD5A2 P31213 1/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
GRN P28799 1/20 0.41
SORT1 Q99523 1/20 0.41
HDAC3 O15379 1/20 0.40
HDAC4 P56524 1/20 0.40
HDAC1 Q13547 1/20 0.40
HDAC7 Q8WUI4 1/20 0.40
HDAC2 Q92769 1/20 0.40
HDAC10 Q969S8 1/20 0.40
HDAC11 Q96DB2 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
HDAC9 Q9UKV0 1/20 0.40
HDAC5 Q9UQL6 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21099277 0.82 KDM4E (0.50) TSHRHPGDNPFFR2MEN1KMT2A
SCHEMBL1988443 0.77 TSHR (0.48) TSHRHPGDNPFFR2SRD5A2MEN1
SCHEMBL8461563 0.77 MAPT (0.35) MEN1KMT2ASMN1; SMN2KDM4EMAPT
SCHEMBL31599679 0.76 TSHR (0.52) TSHRHPGDNPFFR2SRD5A2MEN1
SCHEMBL2014424 0.76 TSHR (0.52) TSHRHPGDNPFFR2SRD5A2MEN1
SCHEMBL2012718 0.76 CES2 (0.42) TSHRMAPT
SCHEMBL760302 0.75 TSHR (0.57) TSHRHPGDSRD5A2MEN1KMT2A
SCHEMBL23792292 0.75 HPGD (0.50) TSHRHPGDNPFFR2GRNSORT1
SCHEMBL2012003 0.73 HTT (0.47) TSHRHPGDSMN1; SMN2KDM4EMAPT
SCHEMBL8464546 0.73 KMT2A (0.39) HPGDMEN1KMT2ASMN1; SMN2HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102652159-B Stain-resistant aqueous coating composition AKZO NOBEL COATINGS INT BV 2014-08-13 CN disclosed
EP-2513237-B1 STAIN-BLOCKING AQUEOUS COATING COMPOSITION AKZO NOBEL COATINGS INT BV (NL) 2014-06-18 EP disclosed
US-8709609-B2 Stain-blocking aqueous coating composition AKZO NOVEL COATINGS INTERNATIONAL B.V. (NL) 2014-04-29 US disclosed
EP-2513237-A1 STAIN-BLOCKING AQUEOUS COATING COMPOSITION Akzo Nobel Coatings International B.V. (NL) 2012-10-24 EP disclosed
US-20120244368-A1 STAIN-BLOCKING AQUEOUS COATING COMPOSITION AKZO NOBEL COATING INTERNATIONAL B.V. (NL) 2012-09-27 US disclosed
WO-2011073164-A1 STAIN-BLOCKING AQUEOUS COATING COMPOSITION AKZO NOBEL COATINGS INTERNATIONAL B.V. (NL) 2011-06-23 WO disclosed
EP-0197274-B1 PROCESS FOR THE PREPARATION OF SUBSTITUTED STYRENES BAYER AG (DE) 1989-01-04 EP disclosed
US-4650910-A CLEAVAGE OF N-ACYL-B-PHENETHYLAMINES WITH BASE BAYER AKTIENGESELLSCHAFT (DE) 1987-03-17 US disclosed
EP-0197274-A1 Process for the preparation of substituted styrenes BAYER AG (DE) 1986-10-15 EP disclosed