Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MPI | P34949 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2016046 | 0.87 | SMO (0.49) | SMOKMT2ANPSR1MAPTHTT | |
| SCHEMBL2163782 | 0.83 | SMO (0.51) | SMOKMT2ANPSR1MAPTHTT | |
| SCHEMBL2012113 | 0.83 | METAP2 (0.46) | KMT2ANPSR1MAPTHTTMEN1 | |
| SCHEMBL2016804 | 0.83 | SLC6A7 (0.47) | SMOKMT2ANPSR1MAPTHTT | |
| SCHEMBL2011899 | 0.83 | ALDH1A1 (0.44) | KMT2ANPSR1MAPTHTTMEN1 | |
| SCHEMBL2013930 | 0.83 | AKR1C3 (0.43) | KMT2ANPSR1MAPTHTTMEN1 | |
| SCHEMBL2015986 | 0.82 | L3MBTL1 (0.48) | KMT2ANPSR1MAPTHTTMEN1 | |
| SCHEMBL2017794 | 0.81 | MAPT (0.61) | KMT2ANPSR1MAPTHTTMEN1 | |
| SCHEMBL2054055 | 0.81 | SMO (0.49) | SMOKMT2ANPSR1MAPTHTT | |
| SCHEMBL2013450 | 0.81 | IDE (0.45) | KMT2ANPSR1MAPTHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |