Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 3/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 6/20 | 0.35 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.30 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | RXRA | P19793 | 1/20 | 0.30 |
| ▸ | RXRB | P28702 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2026164 | 0.90 | LMNA (0.36) | CSNK1EGRIA1TDP1 | |
| SCHEMBL2016014 | 0.89 | KDM4A (0.32) | GRIA1RXRA | |
| SCHEMBL2026353 | 0.88 | TUBB4A (0.36) | — | |
| SCHEMBL2022349 | 0.81 | GRIA1 (0.35) | GRIA1TDP1 | |
| SCHEMBL2027341 | 0.80 | MEN1 (0.36) | GRIA1 | |
| SCHEMBL2021495 | 0.78 | ZAP70 (0.40) | GRIA1 | |
| SCHEMBL2019721 | 0.78 | ADORA3 (0.37) | GRIA1 | |
| SCHEMBL2195004 | 0.77 | CSNK1E (0.35) | CSNK1EGRIA1HASPINGPBAR1RXRA | |
| SCHEMBL12575063 | 0.75 | CSNK1E (0.40) | CSNK1EGRIA1HASPIN | |
| SCHEMBL2026310 | 0.75 | ADORA3 (0.50) | TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8329705-B2 | Substituted triazolo-pyrazine compounds | ARQULE, INC. (US) | 2012-12-11 | — | — | US | disclosed |
| WO-2011082267-A2 | SUBSTITUTED TRIAZOLO-PYRAZINE COMPOUNDS | ARQULE, INC. (US) | 2011-07-07 | — | — | WO | disclosed |
| US-20110160215-A1 | Substituted Triazolo-Pyrazine Compounds | ARQULE, INC. (US) | 2011-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160215-A1 | Substituted Triazolo-Pyrazine Compounds | MKI67, TP53, THPO | CSNK1E 1488/4885GRIA1 2924/4885HASPIN 820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.