Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GHSR | Q92847 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9388103 | 0.92 | MAPT (0.44) | MAPTSMN1; SMN2LMNAL3MBTL1KDM4E | |
| SCHEMBL20195249 | 0.86 | MAPT (0.50) | ACACBMAPTLMNAL3MBTL1KDM4E | |
| SCHEMBL20395324 | 0.83 | ACACB (0.40) | ACACBMAPTSMN1; SMN2GHSRLMNA | |
| SCHEMBL3229511 | 0.80 | NNMT (0.44) | ACACBMAPTSMN1; SMN2LMNAKDM4E | |
| SCHEMBL19405295 | 0.79 | APP (0.40) | ACACBMAPTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL30942648 | 0.79 | CA2 (0.38) | ACACBMAPTL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL9829221 | 0.79 | ACACB (0.41) | ACACBMAPTGHSRLMNACYP3A4 | |
| SCHEMBL300799 | 0.79 | PIK3CD (0.43) | ACACBMAPTSMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL9360618 | 0.77 | ACACB (0.40) | ACACBMAPTGHSRLMNACYP3A4 | |
| SCHEMBL13848403 | 0.77 | KDM4E (0.41) | ACACBMAPTSMN1; SMN2L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2729447-B1 | POSITIVE ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTOR | H LUNDBECK AS (DK) | 2018-05-30 | — | — | EP | disclosed |