Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ACACB | O00763 | 7/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PI4KA | P42356 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20195254 | 0.86 | ACACB (0.42) | MAPTACACBCYP4F2CYP4A11L3MBTL1 | |
| SCHEMBL2488282 | 0.85 | MAPT (0.53) | MAPTACACBCYP19A1S1PR1S1PR3 | |
| SCHEMBL20784571 | 0.85 | MAPT (0.49) | MAPTACACBCYP19A1L3MBTL1RAB9A | |
| SCHEMBL9388103 | 0.84 | MAPT (0.44) | MAPTL3MBTL1RAB9AKDM4EMEN1 | |
| SCHEMBL3229511 | 0.83 | NNMT (0.44) | MAPTACACBCYP4F2CYP4A11PIK3CA | |
| SCHEMBL5530443 | 0.81 | RAB9A (0.53) | MAPTACACBCYP19A1L3MBTL1RAB9A | |
| SCHEMBL30942648 | 0.81 | CA2 (0.38) | MAPTACACBCYP4F2CYP4A11L3MBTL1 | |
| SCHEMBL18397128 | 0.81 | MAPT (0.46) | MAPTACACBCYP19A1L3MBTL1RAB9A | |
| SCHEMBL12141547 | 0.80 | MAPT (0.52) | MAPTACACBCYP19A1L3MBTL1RAB9A | |
| SCHEMBL20195258 | 0.79 | ACACB (0.47) | ACACBCYP4F2CYP4A11S1PR1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2729447-B1 | POSITIVE ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTOR | H LUNDBECK AS (DK) | 2018-05-30 | — | — | EP | disclosed |