Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 3/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PHGDH | O43175 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21779746 | 0.85 | CHKA (0.48) | CHKAALDH1A1KDM4ESMN1; SMN2NR1H2 | |
| SCHEMBL15265082 | 0.84 | ALDH1A1 (0.51) | ALDH1A1KDM4EPDE2APOLBTDP1 | |
| SCHEMBL20198110 | 0.82 | CHKA (0.42) | CHKANR1H2MPO | |
| SCHEMBL22365070 | 0.82 | CHKA (0.55) | CHKAALDH1A1KDM4ESMN1; SMN2ABCB1 | |
| SCHEMBL14924465 | 0.78 | KDM4E (0.50) | CHKAALDH1A1KDM4ESMN1; SMN2NR1H2 | |
| SCHEMBL16121936 | 0.77 | CHKA (0.74) | CHKAALDH1A1KDM4EPOLBTDP1 | |
| SCHEMBL10819382 | 0.76 | KDM4E (0.70) | ALDH1A1KDM4ESMN1; SMN2NR1H2MPO | |
| SCHEMBL20198122 | 0.76 | RPS6KA3 (0.45) | CHKAPDE2A | |
| SCHEMBL27938056 | 0.76 | IKBKE (0.47) | CHKA | |
| SCHEMBL30074247 | 0.76 | MGLL (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3698782-A1 | CARBAMATE COMPOUNDS FOR USE IN THERAPY | Lundbeck La Jolla Research Center, Inc. (US) | 2020-08-26 | — | — | EP | disclosed |
| EP-2800565-B1 | CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME | LUNDBECK LA JOLLA RESEARCH CENTER INC (US) | 2020-03-25 | — | — | EP | disclosed |
| EP-3326627-A1 | CARBAMATE COMPOUNDS AND OF MAKING AND USING SAME | Abide Therapeutics, Inc. (US) | 2018-05-30 | — | — | EP | disclosed |