Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 4/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | MERTK | Q12866 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20198160 | 0.88 | HTR3E (0.41) | CHKASCN9AHTR3EHTR3BHTR3A | |
| SCHEMBL15093704 | 0.87 | LMNA (0.43) | TGFBR1THRBMTORJAK2JAK1 | |
| SCHEMBL20198123 | 0.86 | ALDH1A1 (0.43) | SCN9ANPC1TGFBR1THRBJAK2 | |
| SCHEMBL15263968 | 0.85 | ALDH1A1 (0.47) | SCN9AJAK2JAK1TYK2JAK3 | |
| SCHEMBL15266376 | 0.83 | TGFBR1 (0.39) | SCN9ANPC1TGFBR1THRBAXL | |
| SCHEMBL20198126 | 0.82 | CHKA (0.48) | CHKAMPONR1H2 | |
| SCHEMBL15093900 | 0.80 | ALDH1A1 (0.48) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL15263832 | 0.78 | ALDH1A1 (0.46) | SCN9AAXLMERTKJAK2JAK1 | |
| SCHEMBL15100956 | 0.78 | MGLL (0.57) | — | |
| SCHEMBL21779746 | 0.78 | CHKA (0.48) | CHKAMPONR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2800565-B1 | CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME | LUNDBECK LA JOLLA RESEARCH CENTER INC (US) | 2020-03-25 | — | — | EP | disclosed |
| EP-3326627-A1 | CARBAMATE COMPOUNDS AND OF MAKING AND USING SAME | Abide Therapeutics, Inc. (US) | 2018-05-30 | — | — | EP | disclosed |