Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25659073 | 0.80 | ALDH1A1 (0.35) | CYP1A2POLBHRH4 | |
| SCHEMBL28232873 | 0.78 | HRH4 (0.36) | CYP1A2POLBHRH4 | |
| SCHEMBL1767952 | 0.75 | HRH4 (0.41) | CYP1A2POLBHRH4 | |
| SCHEMBL12295188 | 0.74 | POLB (0.40) | CYP1A2POLBHRH4 | |
| SCHEMBL22240245 | 0.72 | L3MBTL1 (0.44) | HRH4 | |
| SCHEMBL22408906 | 0.71 | CA2 (0.38) | — | |
| SCHEMBL503392 | 0.70 | — | — | |
| SCHEMBL4871004 | 0.70 | — | — | |
| Dimethylamine SCHEMBL9053689 | 0.69 | HRH4 (0.45) | CYP1A2POLBHRH4 | |
| SCHEMBL22121995 | 0.68 | CYP2C19 (0.38) | CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3033336-B1 | INHIBITORS OF PLASMA KALLIKREIN | KALVISTA PHARMACEUTICALS LTD (GB) | 2018-05-30 | — | — | EP | disclosed |