Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | RCOR1 | Q9UKL0 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | LIG1 | P18858 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | LSS | P48449 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL11481432 | 0.70 | MAPK1 (0.49) | MAP1LC3BHTR3AKDM1ARCOR1DRD2 | |
| SCHEMBL11481127 | 0.69 | MAPK1 (0.47) | MAP1LC3BHTR3ASRD5A1SLC6A3MAPK1 | |
| SCHEMBL4339855 | 0.67 | KDM1A (0.53) | KDM1ARCOR1MAPK1LIG1MEN1 | |
| SCHEMBL30074982 | 0.66 | TRPA1 (0.47) | HTR3AKDM1ARCOR1DRD2SRD5A1 | |
| SCHEMBL1858459 | 0.66 | HTR3A (0.37) | MAP1LC3BHTR3AKDM1ARCOR1DRD2 | |
| SCHEMBL31622423 | 0.65 | HTR3A (0.48) | HTR3AKDM1ARCOR1DRD2SLC6A3 | |
| SCHEMBL27276966 | 0.65 | KDM1A (0.43) | HTR3AKDM1ARCOR1DRD2SRD5A1 | |
| SCHEMBL19502447 | 0.65 | HTR3A (0.44) | MAP1LC3BHTR3ADRD2SRD5A1SLC6A3 | |
| SCHEMBL315186 | 0.65 | HTR3A (0.58) | HTR3ADRD2SRD5A1SLC6A3SLC6A2 | |
| Methyl Alcohol SCHEMBL15391253 | 0.65 | DRD2 (0.55) | HTR3ADRD2SRD5A1SLC6A3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3544979-B1 | OXADIAZOLONES AS TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-08-04 | — | — | EP | disclosed |
| WO-2018096159-A1 | OXADIAZOLONES AS TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2018-05-31 | — | — | WO | disclosed |