Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1948604 | 0.81 | LMNA (0.47) | ALDH1A1KMT2ARAB9AL3MBTL1MEN1 | |
| SCHEMBL22667768 | 0.73 | TP53 (0.55) | ALDH1A1NPC1RAB9AL3MBTL1POLB | |
| SCHEMBL13233264 | 0.72 | ALDH1A1 (0.67) | NPSR1ALDH1A1KMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL18541207 | 0.71 | L3MBTL1 (0.38) | ALDH1A1KMT2ASMN1; SMN2RAB9AL3MBTL1 | |
| SCHEMBL18541208 | 0.71 | MAPT (0.41) | ALDH1A1KMT2ASMN1; SMN2L3MBTL1CYP2C19 | |
| SCHEMBL12926858 | 0.70 | NPC1 (0.56) | KMT2ASMN1; SMN2NPC1RAB9ATRPV1 | |
| SCHEMBL13233328 | 0.70 | KMT2A (0.68) | NPSR1ALDH1A1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL9157833 | 0.69 | MAPT (0.60) | ALDH1A1SMN1; SMN2RAB9AL3MBTL1CYP2C19 | |
| SCHEMBL15434485 | 0.69 | MTNR1B (0.54) | ALDH1A1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL24590187 | 0.68 | HDAC3 (0.58) | ALDH1A1KMT2ASMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10682419-B2 | Prodrugs of peptide epoxy ketone protease inhibitors | ONYX THERAPEUTICS, INC. (US) | 2020-06-16 | — | — | US | disclosed |
| US-20180147291-A1 | PRODRUGS OF PEPTIDE EPOXY KETONE PROTEASE INHIBITORS | ONYX THERAPEUTICS, INC. | 2018-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180147291-A1 | PRODRUGS OF PEPTIDE EPOXY KETONE PROTEASE INHIBITORS | PREP, VIP, PEPD | NPSR1 663/4885ALDH1A1 1285/4885KMT2A 2378/4885 |
| US-10682419-B2 | Prodrugs of peptide epoxy ketone protease inhibitors | PREP, VIP, PEPD | NPSR1 663/4885ALDH1A1 1285/4885KMT2A 2378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.